Clinical efficacy of self-made Bitong decoction in lumbar disc herniation patients with cold-dampness syndrome
10.12173/j.issn.2097-4922.202409022
- VernacularTitle:自拟痹痛汤对寒湿痹阻型腰椎间盘突出症的临床疗效
- Author:
Hewei ZHUO
1
;
Zhenni ZHENG
;
Youping JIN
Author Information
1. 浙江中医药大学附属丽水市中医院肾病风湿科(浙江丽水 323000)
- Keywords:
Self-made Bitong decoction;
Cold-dampness syndrome;
Lumbar disc herniation;
Etoricoxib tablets;
Interleukin;
Tumor necrosis factor;
Adverse reaction
- From:
China Pharmacist
2024;28(11):451-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical efficacy of self-made Bitong decoction(SBD)combined with etoricoxib tablets(ET)in lumbar disc herniation(LDH)patients with cold-dampness syndrome(CDS).Methods The clinical data of LDH patients attending Lishui Hospital of Traditional Chinese Medicine affiliated to Zhejiang University of Traditional Chinese Medicine from January 2023 to January 2024 were retrospectively analyzed and divided into the ET group and the ET+SBD group according to the treatment plans.The main observed indicators of this study were quality of life[Oswestry Dysfunction Index(ODI)]and pain level[Visual Analog Scale(VAS)],functional status[Modified Japanese Orthopedic Association,M-JOA)scale],treatment response rate,TCM syndrome score and inflammatory factors(IL-1β,TNF-α,and IL-6)after 4 weeks of treatment.The occurrence of adverse reactions during the medication period was recorded to evaluate the safty.Results A total of 86 patients were included in the study,40 in the ET group and 46 in the ET+SBD group.After treatment,the ODI score,VAS score,M-JOA score,TCM syndrome score,IL-1 β,TNF-α and IL-6 levels were significantly lower in the ET+SBD group than those in the ET group,and the treatment efficiency was higher than that in the ET group(P＜0.05).In addition,there was no statistically significant difference between the incidence of adverse events in the ET+SBD group and the ET group(P＞0.05).Conclusion SBD combined with ET can significantly improve the quality of life,pain degree and functional status of LDH patients,and improve the treatment effect,which is closely related to the anti-inflammatory and analgesic effect of SBD.
