Research progress on chemical constituents,pharmacological effects and toxicity of Dictamni cortex
10.12173/j.issn.2097-4922.202406157
- VernacularTitle:白鲜皮化学成分、药理作用及毒性研究进展
- Author:
Wenkai HU
1
;
Xiaomin XU
;
Xin JIANG
;
Jiameixue WO
;
Suxia JIA
;
Shumin LIU
;
Fang LU
Author Information
1. 黑龙江中医药大学研究生院,哈尔滨 150040
- Keywords:
Dictamni cortex;
Chemical constituents;
Pharmacological effects;
Toxicity;
Research progress;
Alkaloids;
Sesquiterpenes;
Limonoids;
Fatty acids
- From:
China Pharmacist
2024;28(10):252-267
- CountryChina
- Language:Chinese
-
Abstract:
Dictamni cortex is the root bark of Rutaceae plants.It is the main medicinal part and the key drug of 'Zhuhuang Fengbi'.It has the effects of clearing heat and detoxifying,dispelling wind and drying dampness,and relieving itching.Dictamni cortex mainly contains 228 chemical components such as alkaloids,sesquiterpenes,limonoids,fatty acids,volatile oils,flavonoids,steroids,etw.Its pharmacological activities in vivo and in vitro include antibacterial activity,anti-inflammatory activity,hepatoprotective activity,cardiovascular protection activity,insecticidal activity,anticancer activity,anti-allergic activity,and improvement of gastrointestinal activity.It has been reported that Dictamni cortex also has potential hepatotoxicity,among which dictamnine,fraxinellone and limonin compounds are potential hepatotoxic components.In this paper,the chemical constituents,pharmacological effects and toxicity of Dictamni cortex are reviewed by consulting domestic and foreign literature,to provide theoretical support for the clinical rational application and related product development of Dictamni cortex.
