Clinical effect of bone melon extract combined with loronoxicam in elderly patients after total hip arthroplasty
10.12173/j.issn.1008-049X.202404066
- VernacularTitle:骨瓜提取物联合氯诺昔康对全髋关节置换术后老年患者的临床效果
- Author:
Kaili ZHANG
1
;
Xin FAN
;
Lingtong SUN
Author Information
1. 杭州市西溪医院骨科(杭州 310023)
- Keywords:
Bone melon extract;
Clonoxicam;
Total hip arthroplasty;
Efficacy;
Femoral neck fracture;
Elderly;
C-reactive protein;
Tumor necrosis factor-α
- From:
China Pharmacist
2024;27(8):1320-1326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of bone melon extract(BME)combined with lornoxicam(LN)in elderly patients after total hip arthroplasty.Methods Elderly patients with femoral neck fracture attending the Department of Orthopedics of Xixi Hospital in Hangzhou City from January 2020 to June 2023 were retrospectively selected as study subjects.According to different postoperative treatment programs,they were divided into the BME group(LN combined with BME treatment)and the LN group(LN treatment).The visual analog scores(VAS)and Oswestry dysfunction index questionnaire(ODI)scores of patients in the two groups preoperatively and postoperatively,the changes of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)]before surgery and 4 weeks after surgery,and the clinical efficacy of patients in the two groups preoperatively and at 6 months postoperatively,the hip joint function(Harris score),daily living ability[Barthel index(BI)]and quality of life[Mos36-Item Short Form Health Survey(SF-36)]were compared.Results A total of 100 patients were included in the study,with 56 in the BME group and 44 in the LN group.Before treatment,the differences in VAS scores,ODI scores,inflammatory factors,Harris scores,BI and SF-36 between the two groups were not statistically significant(P＞0.05).After treatment,VAS scores,ODI scores,CRP,IL-6 and TNF-αdecreased significantly in both groups compared with those before treatment(P＜0.05);and these indicators in the BME group were lower than those in the LN group(P＜0.05).In terms of therapeutic efficacy,the therapeutic efficiency of the BME group was significantly higher than that of the LN group(P＜0.05).Harris scores,BI and SF-36 significantly increased in both groups(P＜0.05),and these in the BME group were greater than those in the LN group(P＜0.05).Conclusion Compared with LN treatment alone,BME combined with LN can promote rapid recovery in elderly patients after total hip arthroplasty.
