Research on the rheological properties of terbinafine hydrochloride cream
10.12173/j.issn.1008-049X.202402143
- VernacularTitle:盐酸特比萘芬乳膏流变学性质的研究
- Author:
Qianqian CHEN
1
,
2
;
Zhengping LIU
;
Shuolei LI
;
Song XUE
;
Dawei LI
Author Information
1. 山东省药学科学院(济南 250108)
2. 新型缓控释制剂与药物靶向递送系统山东省工程研究中心(济南 250108)
- Keywords:
Terbinafine hydrochloride cream;
Rheology;
Original drug;
Generic drug;
Yield stress;
Viscosity;
Modulus;
Creep recovery
- From:
China Pharmacist
2024;27(8):1296-1302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the rheological properties of terbinafine hydrochloride cream,and provide a research basis for the consistency of this product.Methods The Kinexus rheometer was used to determine the dynamic and steady rheological parameters of terbinafine hydrochloride cream.Comparative studies on the rheological curves,yield stress,viscosity measurement,linear viscoelasticity and creep recovery of original and generic terbinafine hydrochloride cream were carried out.Results The original and generic terbinafine hydrochloride cream were both non-Newtonian fluid with shear thinning.The yield stress of three generic were similar to the original.The linear viscoelastic region of three generic were similar to the original,and the ranges of linear viscoelastic were both 0.01％-1％,the elastic moduli were all greater than the viscosity moduli and were viscoelastic materials.It could be seen from the creep recovery curve that the creep behavior of three generic were basically the same with the original.Conclusion Among the six terbinafine hydrochloride creams measured experimentally,the rheological properties of most generic drugs are basically the same as the original.
