Pilot study of budesonide and montelukast sodium in the treatment of children with bronchial asthma based on interesting respiratory rehabilitation training
10.12173/j.issn.1008-049X.202405060
- VernacularTitle:布地奈德及孟鲁司特钠治疗支气管哮喘患儿试点研究:基于趣味性呼吸康复训练
- Author:
Xuehong WANG
1
;
Xiaoqin YI
;
Yanhua YUAN
Author Information
1. 马鞍山十七冶医院儿科(安徽马鞍山 243000)
- Keywords:
Bronchial asthma;
Interesting respiratory rehabilitation training;
Budesonide;
Montelukast sodium;
Lung function;
Inflammatory factors
- From:
China Pharmacist
2024;27(7):1192-1201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of interesting respiratory rehabilitation training(IRRT)combined with budesonide and montelukast sodium in the treatment of bronchial asthma(BA).Methods This is a pilot clinical research.Children with BA who visited Ma'anshan Shiqiye Hospital of Anhui province from January 2023 to December 2023 in were prospectively recruited as study subjects,and were divided into the IRRT group and the conventional group according to the random number table method.After 8 weeks of continuous intervention,the clinical efficacy,recovery of related symptoms and adverse reactions of BA children were evaluated.The changes in lung function parameters,inflammation indicators and quality of life were compared before and after treatment in the IRRT group and the conventional group,and the changes in lung function parameters,inflammation indicators and quality of life between the IRRT group and the conventional group after treatment were compared.Results A total of 120 BA children were included in the study,with 60 cases in each group.Before treatment,there was no significant difference in baseline data such as age and gender between the two groups(P>0.05).After 8 weeks of treatment,pulmonary function parameters,inflammation indicators,and quality of life were all improved in the IRRT group and the conventional group,(P<0.05),and the improvement in the IRRT group was better than that in the conventional group(P<0.05).In addition,the disappearance time of wheezing,disappearance time of cough,and disappearance time of dyspnea were significantly shorter than those in the conventional group(P<0.05).In terms of safety,no significant serious adverse effects were seen in the IRRT group and the conventional group.Conclusion Adjuvant IRRT therapy can significantly improve children's lung function,reduce the level of inflammatory factors,shorten the course of the disease,improve quality of life,and promote early recovery in children.
