Research progress on determination methods of carbocisteine
10.12173/j.issn.1008-049X.202401138
- VernacularTitle:羧甲司坦含量测定方法的研究进展
- Author:
Yuxuan XIN
1
;
Yongjiu QIN
;
Xinyuan XU
Author Information
1. 徐汇食品药品检验所(上海 200030)
- Keywords:
Carbocisteine;
Determination;
Spectrometry;
Chromatography;
Chronic obstructive pulmonary disease;
Dispelling phlegm;
Research progress
- From:
China Pharmacist
2024;27(5):892-900
- CountryChina
- Language:Chinese
-
Abstract:
Carbocisteine is a commonly used expectorant drug.Currently,the reported detection methods for carbocisteine mainly include the electrochemical method,potassium bromated titration,kineticmethod,spectrometry,chromatography,HPLC-FLD precolumn derivation determination,HPLC-MS,etc.The advantages and disadvantages of each method were compared and analyzed in this paper,and it is found that HPLC was more suitable for the quality analysis of carbocisteine,which could serve as a reference for upgrading standard of carbocisteine content determination.
