Research progress of celastrol in the treatment of stroke
10.12173/j.issn.1008-049X.202312187
- VernacularTitle:雷公藤红素用于脑卒中治疗的研究进展
- Author:
Ronghui ZHU
1
;
Li CHEN
;
Yang CHEN
;
Yue HUANG
;
Yunhua ZHENG
;
Tao QIU
Author Information
1. 仁寿县人民医院药剂科(四川眉山 620599)
- Keywords:
Celastrol;
Pharmacological mechanisms;
Stroke;
Ischemic stroke;
Hemorrhagic stroke
- From:
China Pharmacist
2024;27(4):711-721
- CountryChina
- Language:Chinese
-
Abstract:
Celastrol is extracted from the traditional Chinese medicine Tripterygium wilfordii Hook.f..It is a kind of traditional Chinese medicine monomer with extensive pharmacological activity and has anti-tumor,anti-inflammation,anti-oxidation and neuroprotective effects.Studies have found that celastrol is not only closely related to obesity,tumor and cardiovascular diseases,but also plays a neuroprotective role in the cerebrovascular system by regulating various signaling pathways.At present,effective drugs for stroke are still limited,but with the deepening of the research on celastrol,its therapeutic potential in stroke has received more and more attention,especially in ischemic and hemorrhagic stroke,which has shown good therapeutic effects.Therefore,this is the first time to systematically summarize the therapeutic effects of celastrol on stroke and the underlying mechanisms involved,in order to provide further directions and references for the neuroprotective effects of celastrol.
