Research on the sources,structures and identification technology of glucosamine drugs
10.12173/j.issn.1008-049X.202311269
- VernacularTitle:氨基葡萄糖类药物的来源、结构及其鉴别技术研究
- Author:
Xiaomeng DAN
1
,
2
;
Xiaofeng LIU
;
Jianghong GUO
;
Hong JIANG
Author Information
1. 湖北省药品监督检验研究院(武汉 430073)
2. 国家药品监督管理局血液制品质量控制重点实验室(武汉 430073)
- Keywords:
Hydrochloric glucosamine;
Sulfate glucosamine;
Source;
Structure;
Identification
- From:
China Pharmacist
2024;27(4):551-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To sort out and summarize the researches of source,structures and identification technologies of glucosamine drugs,and provide a reference for the development and research of this kind of drugs.Methods The sources of glucosamine drugs was identified by stable isotope ratio test,and the crystal structures of glucosamine drugs was identified by X-ray powder diffraction.Results When the carbon isotope ratio was between-11‰ and-13‰,the source of glucosamine was from microbial fermentation.When the carbon isotope ratio was between-17‰ and-24‰,the source of glucosamine was from microbial animals.The 2θ angles of the strongest diffraction peak of hydrochloric glucosamine were 16.525°,12.360° and 17.330°,the 2θ angles of the strongest diffraction peak of sodium sulfate were 32.124° and 19.035,the 2θ angle of the strongest diffraction peak of the glucosamine sulfate potassium chloride/sodium was 27.036°,and the 2θ angle of the strongest diffraction peak of the physical mixture of glucosamine hydrochloride and chloride/sodium sulfate(2∶1)was 12.391°.Through X-ray powder diffraction technology,the glucosamine sulfate potassium chloride/sodium eutectic complex salt and the physical mixture of glucosamine hydrochloride and chloride/sodium sulfate.can be distinguished.Conclusion The research can effectively identify the sources and structures of glucosamine drugs,which is simple,accurate and reliable,and provides technical support for the supervision and management of glucosamine drugs.
