Investigation on the effect of decocting gypsum into medicine on calcium content of Xiao'er Magan granules
10.19778/j.chp.2024.02.013
- VernacularTitle:石膏煎煮入药方式对小儿麻甘颗粒钙含量影响的研究
- Author:
Yiqin FEI
1
;
Tao JIANG
;
Pan LÜ
;
Ping YANG
;
Fangling ZHAN
;
Ling XU
Author Information
1. 湖北省药品监督检验研究院/国家药品监督管理局中药质量控制重点实验室/湖北省药品质量检测与控制工程技术研究中心,武汉 430075
- Keywords:
Xiao'er Magan granules;
gypsum;
decoction;
calcium content;
comminution degree;
influence
- From:
Drug Standards of China
2024;25(2):187-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a microwave digestion and inductively coupled plasma mass spectrometry(ICP-MS)for determination on calcium content of Xiao'er Magan granules and discuss the effect of decocting gypsum into medicine on calcium content.Methods:ICP-MS was adopted to determine the calcium content in the preparation,and the difference of calcium content in the small preparation and Xiao'er Magan granules prepared by different pul-verization degree gypsum and different alcohol precipitation processes were compared.Results:The consistency of calcium content between different enterprises and batches of the same enterprise was poor.The results showed that the larger the particles,the lower the calcium transfer rate.The smaller the particles,the higher the calcium trans-fer rate.Conclusion:The transfer rate of gypsum decocted calcium is related to its degree of comminution to ensure consistency of preparation quality.It is suggested to unify the comminution degree of gypsum.The method can pro-vide guidance for the optimization on preparation technology of Xiao'er Magan granules.
