Research progress in pulmonary toxicity and mechanisms of zinc oxide nanoparticles

VernacularTitle:纳米氧化锌的肺毒性及机制研究进展
Author: Huangbin WANG ¹ ; Min XIONG ; Shasha HUANG ; Liduan HUANG ; Qiufeng XU ; Shuzhen CHEN
Author Information

1. 厦门医学院基础医学部机能与临床转化福建省高校重点实验室,福建厦门 361023
Keywords: zinc oxide nanoparticles; pulmonary toxicity; respiratory exposure; mechanism of toxicity
From: Chinese Journal of Pharmacology and Toxicology 2024;38(11):880-886
CountryChina
Language:Chinese
Abstract: Zinc oxide nanoparticles(ZnO NPs)have been gradually introduced into people's lives due to their excellent properties.In daily contact,ZnO NPs can enter the human body in a variety of ways and accumulate in tissues and organs.Inhalation is an important means by which ZnO NPs enter the human body and deposit in lungs.Studies have shown that exposure of lungs to ZnO NPs will cause a range of negative effects.The mechanism of pulmonary toxicity induced by ZnO NPs is related to Zn2+release,oxidative stress,DNA damage,autophagy,inflammation and pulmonary surfactant dysfunction.This paper reviews the pulmonary toxicity and mechanisms of ZnO NPs,and summarizes the prevention and treatment strategies,which provides scientific basis for safer use of nanomaterials,and potential intervention strategies for the prevention and treatment of nanotoxicity.