Research progress of Hippo/YAP signaling pathway in tissue fibrosis
10.3867/j.issn.1000-3002.2024.11.007
- VernacularTitle:Hippo/YAP信号通路在组织纤维化中的作用研究进展
- Author:
Yingkai MA
1
;
Yongan WANG
;
Yuan LUO
Author Information
1. 军事医学研究院国家安全特需药品全国重点实验室,北京 100850
- Keywords:
Hippo/YAP signaling pathway;
fibrosis;
extracellular matrix;
fibroblasts
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(11):859-871
- CountryChina
- Language:Chinese
-
Abstract:
The Hippo/YAP signaling pathway is an evolutionarily conserved protein kinase cascade that plays an important role in a variety of biological processes,such as cell proliferation and differentia-tion,organ growth and tissue regeneration.Fibrosis is a continuous and highly dynamic process char-acterized by excessive deposition of extracellular matrix,resulting in irreversible pathological changes that eventually lead to the failure of multiple tissues and organs.Targeted therapeutic strategies to ameliorate or reverse fibrosis are lacking.Studies have shown that the aberrantly activated Hippo/YAP signaling pathway may play a role in the development of fibrosis by regulating collagen deposition,fibroblast overproliferation,and epithelial cell differentiation,but the specific mechanism of action has not been fully elucidated.Targeting the Hippo/YAP signaling pathway involves two mechanisms:one is to target the upstream molecules of the Hippo/YAP signaling pathway,which is mainly achieved by inhibiting the activity of the core kinase or blocking the interaction with other molecules;the other is to target the downstream activities of YAP/TAZ and YAP/TAZ-TEAD in the Hippo/YAP signaling pathway.Studies have shown that the phosphorylation and subcellular localization of YAP/TAZ are significantly altered when tissue and organ damage occurs.This article is intended to review the current research on Hippo/YAP signaling pathway and its mediation of fibrosis in the lung,heart,liver,kidney,pancreas and skin in hopes of providing new ideas for studies on the pathogenesis of fibrosis and targeted thera-peutic drugs.
