Research advance in roles of glucagon-like peptide-1 receptor agonists in drug addiction

VernacularTitle:胰高血糖素样肽1受体激动剂在药物成瘾中的作用研究进展
Author: Guanyi LU ¹ ; Qingmei DENG ; Ning WU ; Jin LI
Author Information

1. 军事医学研究院国家安全特需药品全国重点实验室,神经精神药理学北京市重点实验室,北京 100850
Keywords: glucagon-like peptide-1; glucagon-like peptide-1 receptor agonists; drug addiction
From: Chinese Journal of Pharmacology and Toxicology 2024;38(11):846-858
CountryChina
Language:Chinese
Abstract: Drug addiction is a major medical and social issue globally,but there is still a lack of ideal clinical treatments.Glucagon-like peptide-1(GLP-1),a key gut-brain peptide,and its receptor agonists have been approved for the treatment of type 2 diabetes and obesity.In recent years,the role of GLP-1 receptor agonists in combating drug addiction has received increasing attention.Based on an overview of the GLP-1 system and its receptor agonist,this article reviews the role of GLP-1 receptor agonists in drug addiction at both the nonclinical and clinical levels by focusing on addictive psychoactive substances(including alcohol,tobacco,cocaine,opioids,and amphetamines).Future developments are also predicted to provide new clues to the mechanism of drug addiction and development of therapeutic drugs.