New approach methodologies for toxicity testing:physiological based toxicokinetics/toxicodynamicsin vitrotoin vivoextrapolation
10.3867/j.issn.1000-3002.2024.10.006
- VernacularTitle:基于生理的毒代/毒效动力学定量体外-体内外推技术
- Author:
Shengnan LIU
1
;
Qiang ZHANG
;
Jingbo PI
Author Information
1. 中国医科大学公共卫生学院,环境应激与慢病防控教育部重点实验室,辽宁沈阳 110122
- Keywords:
new approach methodologies;
next generation risk assessment;
quantitative in vitro to in vivo extrapolation;
physiologically based toxicokinetic;
physiologically based toxicodynamic
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(10):766-772
- CountryChina
- Language:Chinese
-
Abstract:
New approach methodologies(NAMs)based next generation risk assessment for toxicity testing has quietly emerged globally.As an important component of NAMs,quantitative in vitro to in vivo extrapolation(QIVIVE)has come to be one of the significant technologies for chemical toxicity testing and risk assessment,and has gained rapid development and wide applications in the field of toxicology.The implementation of QIVIVE technology relies on two vital branches of computational toxicology:physiologically based toxicokinetics and physiologically based toxicodynamics.The system integrates population research,in vivo/in vitro testing,and computational toxicology research to quantitatively study the nonlinear quantitative relationship between exposure doses and physiological response,providing an efficient and accurate means of toxicity testing for health risk assessment of chemicals.At the same time,utilizing increasingly mature multi omics technologies to obtain high-throughput and effective toxicology information,and drawing a signal network of toxicity occurrence and development in the context of big data can greatly improve the efficiency and range of toxicology research.
