Applications of new approach methodologies in food toxicology research in China
10.3867/j.issn.1000-3002.2024.10.002
- VernacularTitle:新途径方法在中国食品毒理学研究中的应用
- Author:
Hui YANG
1
;
Miaoying SHI
;
Daoyuan YANG
;
Haixia SUI
;
Zhou YU
;
Xudong JIA
Author Information
1. 国家食品安全风险评估中心,北京 100021
- Keywords:
new approach methodologies;
food toxicology;
alternative methods;
food safety;
risk assessment
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(10):734-741
- CountryChina
- Language:Chinese
-
Abstract:
Food toxicology plays a crucial role in supporting scientific and technical aspects of food safety risk assessment.However,traditional methods relying on animal testing are becoming increas-ingly inadequate for identifying and evaluating emerging foods and unknown risks.There is a strong push worldwide towards the development of new approach methodologies(NAMs)based on non-animal testing methods.Policies and regulations related to NAMs are being standardized gradually in the European Union,the United States,and China.Some progress has also been made in applying these methodologies in food toxicology research in China.For instance,within the"Food Toxicology Program"at the National Center for Food Safety Risk Assessment,high-content and high-throughput in vitro hazard identification models employing model organisms like human macrophages,hepatocytes,adipocytes,embryonic stem cells,and zebrafish,as well as Toxicological Thresholds of Concern and quantitative in vitro to in vivo extrapolation based on physiologically-based toxicokinetic models have been estab-lished and applied.Nonetheless,new toxicological hazard identification technologies still face challenges such as inadequate elucidation of toxic mechanisms,insufficient collaborative research efforts,and inef-ficient translation of these findings into practical applications.
