Recent progress in key factors that influence in vivo processes of lipid nanomedicines and their pharmacokinetic detection techniques
10.3867/j.issn.1000-3002.2024.09.007
- VernacularTitle:脂质纳米药物体内过程影响因素及药动学检测技术研究进展
- Author:
Huisheng DONG
1
,
2
;
Haoyu XING
;
Qianlong GAO
;
Qifei PAN
;
Qian MA
;
Ying LI
;
Jiefang SUN
Author Information
1. 云南中医药大学中药学院,云南昆明 650500
2. 北京茵诺医药科技有限公司,北京 100915
- Keywords:
lipid nano-drug;
delivery systems;
pharmacokinetics;
in vivo imaging probes;
liquid chromatography-mass spectrometry
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(9):701-709
- CountryChina
- Language:Chinese
-
Abstract:
Over the past 30 years,nano-drug delivery systems(NDDS)have become a promising field of drug research.However,a poor knowledge of the in vivo process of NDDS,the limited methods of pharmacokinetic correlation,and the inability to effectively provide strong support for the construction of upstream drug as well as the evaluation of downstream pharmacology and toxicology have become the technical bottleneck for their clinical transformation.Lipid nanodrug(LND)is the most successful NDDS for industrial transformation with great biocompatibility.Taking LND as an example,this paper reviewed the delivery process and influencing factors in vivo,and summarized the regulatory mecha-nism of biological environments on drug release in vivo.Based on advanced spectroscopy and mass spectrometry techniques,the spatial and temporal distribution of the dynamic carrier particle/depolymer-ized molecule ratio and dynamic free/encapsulated drug ratio of LND in biological matrix were ana-lyzed.Finally,the existing problems and future developments in this field were summarized to provide references for the analysis of NDDS in vivo,and stimulate readers'interest in nanomedical research and development.
