Research progress in action mechanism of small molecular compounds targeting Wnt signaling pathway against osteosarcoma
10.3867/j.issn.1000-3002.2024.09.006
- VernacularTitle:靶向Wnt信号通路的小分子化合物抗骨肉瘤的作用机制研究进展
- Author:
Xue ZHANG
1
;
Jialing LIU
;
Shuang LIU
Author Information
1. 佳木斯大学基础医学院,黑龙江佳木斯 154007
- Keywords:
small molecular compounds;
Wnt signaling pathway;
osteosarcoma
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(9):694-700
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is the most common primary malignant bone tumor in children and adoles-cents.The current treatment methods include immunotherapy,gene therapy,targeted therapy and chemotherapy,but the prognosis is poor and prone to recurrence and metastasis.There is increasing evidence that the Wnt signaling pathway is involved in the entire process of osteosarcoma occurrence,development,metastasis,and prognosis,making it an attractive target.Current research on small molecule compounds related to the Wnt signaling pathway is making progress and attracting more attention so that targeting the Wnt signaling pathway with small molecule compounds has become a promising therapeutic strategy for osteosarcoma.This review focused on the Wnt signaling pathway and introduced the relationship between the Wnt signaling pathway and osteosarcoma,targeting small molecule compounds upstream and downstream of Wnt signaling,analyzed the classification and mechanism of action of related small molecule compounds,and summarized research progress.Target-ing the Wnt signaling pathway,clarifying the specific mechanism,and an intimate knowledge of the complexity of Wnt signaling will help improve the formulation of clinical treatment plans for osteosarcoma,providing references and ideas for the development of anti-tumor drugs related to Wnt regulation.
