Research progress in animal models for depressive disorders and antidepressants
10.3867/j.issn.1000-3002.2024.09.005
- VernacularTitle:抑郁障碍动物模型在抑郁障碍机制和抗抑郁治疗研究中的进展
- Author:
Jingyi JIA
1
;
Zhibo ZHANG
;
Ruiting WEN
;
Linggao ZENG
;
Zhongrui WANG
;
Jianhui LIANG
Author Information
1. 北京大学药学院分子与细胞药理学系,北京 100191
- Keywords:
animal model;
depressive disorders;
stress
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(9):681-693
- CountryChina
- Language:Chinese
-
Abstract:
Animal models are powerful tools for studying the mechanism of depressive disorders and screening antidepressants,but so far there is no model which can stimulate the clinical status of patients ideally.Here,we briefly introduced the research advances in classic animal models of depres-sive disorders,and focused on stress-related animal models,especially those induced by physical and social psychological stressors.The tests for evaluating animal depression behavior were reviewed.In this article,the strengths and weaknesses of each model were analyzed,and the precautions in its application were recommended.Finally,given the high heterogeneity of depressive disorders,this article elaborated on the research progress in models for subtypes of depressive disorders,such as treatment resistant depression,bipolar disorder,peripartum depression,and premenstrual syndrome.
