Research progress in vascularization of renal organoids
10.3867/j.issn.1000-3002.2024.08.008
- VernacularTitle:肾类器官血管化研究进展
- Author:
He LIU
1
,
2
;
Liang YUE
;
Chengjun WU
;
Yingxia TAN
Author Information
1. 大连理工大学医学部生物医学工程学院,辽宁 大连 116000
2. 军事医学研究院,北京 100850
- Keywords:
kidney organoids;
vascularization;
microfluidics;
xenotransplantation;
extracellular matrix
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(8):633-640
- CountryChina
- Language:Chinese
-
Abstract:
Kidney organoids are induced and differentiated from human pluripotent stem cells(PSCs)or adult stem cells(ASCs)derived from tissue sources,primarily composed of nephron struc-tures.However,due to the absence of a supporting vascular network,kidney organoids often exhibit immature tissue structures and limited growth.Therefore,vascularization in kidney organoids remains a pressing challenge in this field.Currently,the methods such as transplantation into immunodeficient animals,alterations in induced differentiation protocols,utilization of microfluidic chips,and manipula-tion of extracellular matrix and oxygen concentrations may facilitate vascularization of kidney organoids,which provides a new perspective for the scientific study and clinical application of kidney organoids.
