Research progress in interactions between SARS-CoV-2 infection and host glycolysis
10.3867/j.issn.1000-3002.2024.08.006
- VernacularTitle:新型冠状病毒感染与宿主糖酵解相互作用研究进展
- Author:
Yuehan LI
1
,
2
;
Lu HAN
;
Wenxia ZHOU
Author Information
1. 广东药科大学中药学院,广东 广州 510006
2. 军事医学研究院国家安全特需药品全国重点实验室,北京 100850
- Keywords:
severe acute respiratory syndrome coronavirus 2;
infection;
glycolysis;
interaction
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(8):610-618
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between glycolysis and viral infectious diseases is close,and the inter-action between viral and host glycolysis is a common mechanism found in a wide range of viruses.Therefore,the regulation of glycolysis may be an important antiviral strategy.The coronavirus diseases 2019 pandemic has brought about a tremendous disaster to humanity,compelling us to seek effective solutions from various perspectives.Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can induce an increase in host glycolysis,the level of which plays an important role in virus replication and infection,associated with the progression of the disease and a variety of clinical symp-toms and complications.The study on the interaction between host glycolysis and SARS-CoV-2 infec-tion can shed light on the pathogenic mechanism of SARS-CoV-2 and promote the research on related drugs.This article reviews the interactions between SARS-CoV-2 infection and host glycolysis in the hopes of providing a new perspective to understand the relationships between viral infections and disease in terms of metabolic regulation and formulate countermeasures.
