Research progress in roles and mechanism of mitophagy in breast cancer
10.3867/j.issn.1000-3002.2024.07.007
- VernacularTitle:线粒体自噬在乳腺癌发生发展中的作用及其调控机制
- Author:
Ye DING
1
;
Jiale WEI
;
Yang XIONG
Author Information
1. 浙江中医药大学 药学院,浙江杭州 310053
- Keywords:
breast cancer;
mitophagy;
PINK1/Parkin;
autophagy receptor protein;
autophagy regu-lator;
chemotherapy resistance
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(7):533-541
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy is a process by which cells selectively eliminate damaged or dysfunctional mitochondria through the autophagy-lysosomal pathway under the regulation of mitophagy-related proteins to maintain mitochondrial quality and cellular homeostasis,and it is closely related to the occurrence and development of a variety of tumors.Increasing studies have shown that mitophagy plays a dual role in breast cancer progression.① Mitophagy promotes breast cancer cell survival and invasion by triggering energy metabolic reprogramming,reducing ROS accumulation and maintaining mitochondrial homeostasis.②Mitophagy leads to death or apoptosis of breast cancer cells by attenuating inflamma-tory responses and triggering mitochondrial damage.The relevant mechanisms include①PTEN induced kinase 1,PINK1(PINK1)/Parkin pathway;② autophagy receptor-associated protein pathway(including BNIP3,BNIP3L and FUNDC1);③ mitochondrial division pathway.This review summarizes the role and mechanism of mitophagy in the hopes of providing reference for research and treatment of breast cancer.
