Dapsone therapy for refractory immune thrombocytopenia patients: a case series.
- Author:
Ji Yun LEE
1
;
Jeong Ok LEE
;
Joo Young JUNG
;
Soo Mee BANG
Author Information
- Publication Type:Original Article
- Keywords: Immune thrombocytopenia; Dapsone; Efficacy; Toxicity
- MeSH: Dapsone*; Humans; Hypersensitivity; Platelet Count; Purpura, Thrombocytopenic, Idiopathic*; Retrospective Studies; Splenectomy; Thrombocytopenia
- From:Blood Research 2017;52(2):95-99
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Dapsone has been recommended as a second-line immunosuppressive agent for patients with immune thrombocytopenia (ITP). METHODS: We retrospectively analyzed the efficacy and safety of dapsone therapy in patients with ITP. RESULTS: Nine ITP patients were treated with dapsone at a dose of 50–100 mg/day between May 2013 and March 2016. All patients were refractory to multiple previous treatments, with a median of 7 agents (range, 4–8), and 3 patients had undergone a previous splenectomy. The median pre-treatment platelet count was 4×10⁹/L (range, 3–27×10⁹/L). Only 1 patient (11.1%) responded to dapsone therapy. No severe adverse events were observed, except for 1 case of dapsone hypersensitivity syndrome. CONCLUSION: Although dapsone is still useful for some patients, it may be ineffective in heavily pretreated patients with profound thrombocytopenia.
