Advances in construction and applications of quantitative adverse outcome pathways in toxicology
10.3867/j.issn.1000-3002.2024.06.009
- VernacularTitle:定量有害结局路径的构建方法及在毒理学中的应用研究进展
- Author:
Mintao LI
1
,
2
;
Jiahui CHEN
;
Beibei JIANG
;
Jie GAO
;
Jiali ZOU
;
Qianru ZHOU
;
Xiaofeng YAN
;
Shuquan LUO
;
Huadong ZHANG
;
Jinyao CHEN
;
Xuemei LIAN
;
Jiao HUO
Author Information
1. 重庆市疾病预防控制中心,重庆 400042
2. 重庆医科大学公共卫生学院,重庆 400016
- Keywords:
quantitative adverse outcome pathway;
toxicity prediction;
risk assessment;
dose-response relationship
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(6):473-480
- CountryChina
- Language:Chinese
-
Abstract:
"Toxicity Testing in the 21st Century—A Vision and Strategy"proposed by the National Research Council of US has brought innovative directives and objectives for toxicity evaluation and risk assessment,pushing forward the next generation of toxicity testing and risk assessment.In this initiative,the concept of adverse outcome pathways(AOPs)has emerged as a prominent methodology,capturing the attention of toxicologists and researchers due to its promising applications in recent years.The quantitative AOP(qAOP)is an extension of the adverse outcome pathway,which is built upon the foundational qualitative adverse outcome pathway model and leverages mathematical frame-works to depict dose-response and/or response-response relationships.This article reviews the princi-ples and advancement surrounding qAOP,introduceds two prevalent methodologies for constructing qAOP,Bayesian network models and regression models,and demonstrates diverse applications of qAOP.Actual cases are used to underscore the transformative role of qAOP in contemporary toxicology and risk assessment practices.
