Methods to establish bladder calculi models in rodents and their applications:a review

VernacularTitle:膀胱结石啮齿类动物模型的制备方法及应用进展
Author: Lifen CHEN ¹ ; Li XU ; Zuyue SUN
Author Information

1. 国家卫生健康委员会生育调节药械重点实验室,上海生殖健康药具工程技术研究中心,上海市生物医药技术研究院,中国生育调节药物毒理检测中心,上海 200237
Keywords: bladder calculi; rodent; animal model; induce
From: Chinese Journal of Pharmacology and Toxicology 2024;38(6):455-461
CountryChina
Language:Chinese
Abstract: Bladder calculi is a type of urinary calculi,which is mostly due to geographical environ-ments,dietary habits,ethnic genetics and diseases of the urinary tract.It is necessary to establish or improve animal models of bladder calculi in order to research the mechanism and develop drugs for the disease.There are 4 types of construction methods for bladder calculi models,which are physical induction,chemical induction,microbial induction and gene knockout models.This review classifies and summarizes the construction methods,characteristics,advantages and disadvantages of rodent ani-mal models for bladder calculi,focusing on the construction processes,cycles and effectiveness.Differ-ent models were compared and problems with the application of present models in drug research and development were pointed out in order to provide reference for the non-clinical effectiveness and safety studies of drugs and devices for the prevention and treatment of bladder calculi.