Effect of 2,5-dimethoxy-4-methylamphetamine on low γ and high-frequency oscillations in rat orbitofrontal cortex
10.3867/j.issn.1000-3002.2024.05.002
- VernacularTitle:2,5-二甲氧基-4-甲基苯丙胺对大鼠眶额叶皮质低γ和高频振荡的影响
- Author:
Yan WANG
1
,
2
;
Kaili JIANG
;
Xiaoyan LIU
;
Ruibin SU
Author Information
1. 南京中医药大学,江苏 南京 210000
2. 军事科学院军事医学研究院国家安全特需药品全国重点实验室,北京 100850
- Keywords:
hallucinogens;
2,5-dimethoxy-4-methylamphetamine;
orbitofrontal cortex;
local field potentials;
γ oscillations;
high frequency oscillations
- From:
Chinese Journal of Pharmacology and Toxicology
2024;38(5):335-343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate possible electrophysiological mechanisms of psychogenic disorders caused by the classical hallucinogen 2,5-dimethoxy-4-methylamphetamine(DOM).METHODS Microelectrode array implantation in the orbitofrontal cortex(OFC)was performed in adult male SD rats.After one week of recovery from surgery,the drugs were administered intraperitoneally to rats in the following order:DOM(0.5,1.5,and 3.0 mg·kg-1),DOM 3.0 mg·kg-1+ketanserin 1.0 mg·kg-1,DOM 3.0 mg·kg-1+SB242084 3.0 mg·kg-1,ketanserin 1.0 mg·kg-1,SB242084 3.0 mg·kg-1.Saline was given as a control group before each drug treatment.The changes of field potential(LFP)in OFC were recorded by the Plexon in vivo multichannel recording system.There was one week of washout of drugs between medications.RESULTS DOM(0.5,1.5 and 3.0 mg·kg-1)increased the power of high frequency oscillations(HFO,P<0.05)but decreased the power of low γ oscillations(P<0.05,P<0.01)in OFC compared to saline.Ketanserin(1.0 mg·kg-1)antagonized DOM induced changes in low γ oscilla-tions(P<0.01)and HFO(P<0.05)power,but SB242084(3.0 mg·kg-1)did not.CONCLUSION DOM can cause such psychoneurological disorders as hallucinations,which may be related to the power decrease of low γ oscillations and increase of HFO in OFC by acting at 5-HT2A receptors.
