Progress in study of multifunctionality of DPP4 and mechanism of action of related drug targets
- VernacularTitle:二肽基肽酶4的多功能性及相关药物靶点作用机制的研究进展
- Author:
Lei WANG
1
,
2
;
Zhi-Hui YANG
;
Yang ZHENG
;
Ying ZHANG
;
Tie-Jian ZHAO
;
Wei-Sheng LUO
;
Tian-Jian LIANG
;
Jia-Hui WANG
Author Information
- Keywords: DPP4; drug targets; inflammation response; tissue repair; energy metabolism; chronic liver disease
- From: Chinese Pharmacological Bulletin 2024;40(12):2212-2217
- CountryChina
- Language:Chinese
- Abstract: DPP4 is a serine exopeptidase that is immobilized on the cell membrane and plays a crucial regulatory role in various physiological and pathological activities within the human body.In addition to acting as a transcription factor to regulate the tran-scription and expression of downstream target genes,DPP4 also functions as a transcription-independent regulator through pro-tein-protein interactions.In recent studies,DPP4 has been strongly linked to various diseases,and several substances with the potential to target DPP4 have been identified.This paper mainly reviews the multifunctionality of DPP4 in regulating vari-ous aspects of energy metabolism,inflammation,tissue repair and carcinogenesis in the body.It also reviews the screening of in vitro inhibitors of DPP4 and its research progress in regulating chronic liver disease,based on the pathological development process of chronic liver disease.
