Research progress on molecular mechanism underlying neuropsychiatric diseases involving NMDA receptor and α2 adrenergic receptor
- VernacularTitle:NMDA受体与α2肾上腺素受体参与神经精神疾病的分子机制研究进展
- Author:
Wen-Xin ZHANG
1
;
Dong-Yu ZHOU
;
Yi HAN
;
Ran JI
;
Lin AI
;
An XIE
;
Xiao-Jing ZHAI
;
Jun-Li CAO
;
Hong-Xing ZHANG
Author Information
- Keywords: N-methyl-D-aspartate receptor; alpha 2 adrenergic receptor; brain-derived neurotrophic factor; depression; Alzhei-mer's disease; neurobiology
- From: Chinese Pharmacological Bulletin 2024;40(12):2206-2212
- CountryChina
- Language:Chinese
- Abstract: Glutamate,norepinephrine,and their receptors com-prise the glutamatergic and norepinephrine systems,which mu-tually affect each other and play essential roles in mediating vari-ous neuropsychiatric diseases.This paper reviews the functions of N-methyl-D-aspartate receptor(NMDA-R)and α2-adrenergic receptor(α2-AR)and their functional crosstalk at the molecular level in brain in common neuropsychiatric diseases,which would benefit our understanding of neuropathophysiology of psychiatric diseases,drug development and optimization of clinical neuro-psychopharmacology.
