Progress on mechanism of action and neuroprotective effects of notoginsenoside R1
- VernacularTitle:三七皂苷R1药理作用机制与神经保护作用研究进展
- Author:
Han-Long WANG
1
,
2
;
Yang SUN
;
Sha-Sha LIU
;
Jun-Peng LONG
;
Qian YAN
;
Yu-Ting LIN
;
Jin-Ping LIANG
;
Shi-Feng CHU
;
Yan-Tao YANG
;
Qi-Di AI
;
Nai-Hong CHEN
Author Information
- Keywords: Panax notoginseng; notoginsenoside R1; mecha-nism of action; research progress; nervous system; neuroprotec-tion
- From: Chinese Pharmacological Bulletin 2024;40(11):2020-2025
- CountryChina
- Language:Chinese
- Abstract: Panax notoginseng is the dried root and rhizome of Panax notoginseng(Burk.)F.H.Chen,a perennial erect herb of the genus Ginseng of the family Wujiaceae.As a traditional Chinese medicine in our country,Panax notoginseng has a good tonic effect,and the Dictionary of Traditional Chinese Medicines has the words that Panax notoginseng is used to tonify the blood,remove the blood stasis and damage,and stop epistaxis.It can also be used to pass the blood and tonify the blood with the best efficacy,and it is the most precious one of the prescription med-icines.Eaten raw,it removes blood stasis and generates new blood,subdues swelling and stabilizes pain,stops bleeding with-out leaving stasis,and promotes blood circulation without hurting the new blood;taken cooked,it can be used to replenish and strengthen the body.Notoginsenoside R1 is a characteristic com-pound in the total saponin of Panax ginseng.In recent years,China's aging has been increasing,and the incidence of neuro-logical disorders has been increasing year by year.Meanwhile,reports on notoginsenoside R1 in the treatment of neurological disorders are increasing,and its neuroprotective effects have been exerted with precise efficacy.The purpose of this paper is to review the treatment of neurological diseases and the mecha-nism of action of notoginsenoside R1,so as to provide a certain theoretical basis for clinical use and new drug development.
