Research progress of PPAR-γ regulating brain cholesterol metabolism to clear β-amyloid protein to improve Alzheimer's disease
- VernacularTitle:PPAR-γ调控脑胆固醇代谢清除β-淀粉样蛋白改善阿尔茨海默病的研究进展
- Author:
Xue-Qing DUAN
1
;
Shao-Feng WANG
;
Xian-Yu CHEN
;
Yan-Wei HAO
;
Jia-Xin LI
;
Li LI
;
Shi-Jun XU
;
Bin LI
Author Information
- Keywords: PPAR-γ; Alzheimer's disease; cholesterol; β-am-yloid protein; natural compounds; Chinese herbal medicine
- From: Chinese Pharmacological Bulletin 2024;40(11):2005-2009
- CountryChina
- Language:Chinese
- Abstract: Peroxisome proliferator-activated receptor gamma(PPAR-γ)is a member of the ligand-activated nuclear tran-scription factor superfamily.Activated PPAR-γ is involved in the regulation of many central nervous system(CNS)events,and is involved in cholesterol metabolism by inducing or inhibi-ting a series of gene pathways,thereby inhibiting the deposition of β-amyloid protein(Aβ).It plays an important neuroprotec-tive role in Alzheimer's disease(AD),improves memory and cognition in AD,and is a potential target for AD.Drug develop-ment aimed at restoring cholesterol homeostasis may be a poten-tial strategy to counteract AD.By analyzing the distribution and structure of PPAR-γ,focusing on the biological correlation be-tween PPAR-γ-mediated cholesterol metabolism and AD,this paper describes the mechanism regulation of PPAR-γ on key proteins,genes and their corresponding molecules,providing a new reference for the treatment of AD.
