Cerulein Pancreatitis: Oxidative Stress, Inflammation, and Apoptosis.
- Author:
Hyeyoung KIM
1
Author Information
1. Department of Food and Nutrition, Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, Korea. kim626@yonsei.ac.kr
- Publication Type:In Vitro ; Review
- Keywords:
Cerulein;
Pancreatitis;
Inflammation;
Apoptosis
- MeSH:
Acinar Cells;
Apoptosis;
Caerulein;
Cytoplasm;
Edema;
Humans;
Inflammation;
NADPH Oxidase;
Oxidative Stress;
Pancreas;
Pancreatitis;
Reactive Oxygen Species;
Transducers
- From:Gut and Liver
2008;2(2):74-80
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cerulein pancreatitis is similar to human edematous pancreatitis, manifesting with dysregulation of digestive enzyme production and cytoplasmic vacuolization, the death of acinar cells, edema formation, and infiltration of inflammatory cells into the pancreas. Reactive oxygen species are involved in nuclear factor-kappaB activation, cytokine expression, apoptosis and pathogenesis of pancreatitis. There is recent evidence that cerulein activates NADPH oxidase, which is a major source of reactive oxygen species during inflammation and apoptosis in pancreatic acinar cells. In addition, the Janus kinase/signal transducer and activator of transcription pathway has been suggested as being involved in inflammatory signaling in the pancreas. This review discusses the involvement of oxidative stress in inflammation and apoptosis in pancreatic acinar cells stimulated with cerulein as an in vitro model of pancreatitis.
