Research progress of NLRP3 inflammasome inhibitors
- VernacularTitle:NLRP3炎症小体抑制剂的研究进展
- Author:
Chen-Guang LI
1
,
2
;
Feng-Yi MAI
;
Jing-Rong LIANG
;
Wen-Tao YANG
;
Jie GUO
;
Jun-Xiang SHU
;
Li-Zu XIAO
Author Information
- Keywords: NLRP3 inflammasome; inhibitor of NLRP3 inflam-masome; endogenous small molecules; low molecular weight compound; natural plant composition; clinical drugs
- From: Chinese Pharmacological Bulletin 2024;40(10):1801-1808
- CountryChina
- Language:Chinese
- Abstract: NLRP3 can recruit proteins such as ASC and pro-caspase1 to form NLRP3 inflammasomes after being stimulated by pathogen and danger signals in vivo,and then induce pyropto-sis and promote the inflammatory reactions to maintain the home-ostasis.However,the overactivation of NLRP3 inflammasomes is closely related to many inflammatory and autoimmune diseases in humans.Targeted inhibition of NLRP3 inflammasomes can sig-nificantly inhibit inflammation and alleviate the relative symp-toms.Therefore,it is an important research direction for treating diseases of NLRP3 inflammasome that searching for effective in-hibitors targeting NLRP3 inflammasome activation and achieving clinical transformation.This review summarizes the latest re-search progress based on the sources of NLRP3 inflammasome inhibitors.
