Mechanism study on treatment of abnormal uterine bleeding by Taohong Siwu Tang based on lipidomics
- VernacularTitle:基于脂质组学的桃红四物汤治疗子宫异常出血的机制研究
- Author:
Meng-Yu SU
1
,
2
;
Yan-Yan ZHANG
;
Rong HUANG
;
Yao CHENG
;
Shan-Shan QIAN
;
Can PENG
;
Dai-Yin PENG
;
Xiao-Chuang LIU
Author Information
- Keywords: lipidomics; Taohong Siwu Tang; abnor-mal uterine bleeding; differential lipid metabolites; UPLC-Q-Exactive Orbitrap/MS; dyslipidemia
- From: Chinese Pharmacological Bulletin 2024;40(9):1649-1657
- CountryChina
- Language:Chinese
- Abstract: Aim To study the effects of Taohong Siwu Tang(TSD)on serum lipid metabolites in rats with abnormal uterine bleeding(AUB),and to analyze the mechanism of action of TSD in improving lipid metabo-lism disorders in AUB.Methods The rat model of AUB was replicated by the method of incomplete abor-tion with drugs,and the lipid metabolites of serum were detected by applying UPLC-Q-Exactive Orbitrap/MS technology,and combined with the principal com-ponent analysis and orthogonal partial least squares-discriminant analysis to screen for differential lipids,the changes of lipids in serum before and after the in-tervention of TSD were clarified.Results A total of 11 differential lipids were screened,mainly phosphati-dyl inositol,phosphatidic acid,phosphatidyl ethanola-mine,phosphatidyl serine,sterol lipids,ceramide,acrylolipids and fatty acids.The screened differential lipids all tended to regress to normal after the adminis-tration of TSD intervention.Conclusion Improvement of AUB by TSD may be related to lipid metabolism such as phosphatidic acid,phosphatidyl inositol,phos-phatidyl ethanolamine,phosphatidyl serine,and ce-ramide.
