Advances in exosomes and Alzheimer's disease

VernacularTitle:外泌体与阿尔茨海默病研究进展
Author: Jin-Ping LIANG ^{1
,

2} ; Yu-Chen ZHU ; Sha-Sha LIU ; Yang SUN ; Bo-Yu KUANG ; Shi-Feng CHU ; Nai-Hong CHEN ; Qi-Di AI ; Yan-Tao YANG
Author Information

1. 湖南中医药大学药学院
2. 湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙 410208
Keywords: Alzheimer's disease; exosomes; exosomal type; drugs; miRNA; extracellular vesicles
From: Chinese Pharmacological Bulletin 2024;40(9):1628-1633
CountryChina
Language:Chinese
Abstract: Exosomes represent a class of nanoscale extracellular vesicles that facilitate the exchange of genetic information among various cells.Alzheimer's disease(AD)stands as a progressive neurodegenerative disorder characterized by its subtle and advan-cing onset,representing the foremost form of dementia lacking effective therapeutic interventions.Notably,investigations have illuminated the involvement of exosomes in the pathogenesis of AD,attributing diagnostic and therapeutic significance to their role,particularly concerning exosomal microRNAs(miRNA).The miRNAs carried by exosomes serve as potential biomarkers for AD,while also exhibiting potential benefits in ameliorating cognitive dysfunction in individuals afflicted by AD.This article aims to comprehensively review the origins of exosomes(encom-passing both mesenchymal cell-derived exosomes and brain-de-rived exosomes)and their potential as therapeutic agents targe-ting AD.