Research progress on neurobiological mechanisms underlying antidepressant effect of ketamine
- VernacularTitle:氯胺酮抗抑郁作用的神经生物学机制研究进展
- Author:
Dong-Yu ZHOU
1
;
Wen-Xin ZHANG
;
Xiao-Jing ZHAI
;
Dan-Dan CHEN
;
Yi HAN
;
Ran JI
;
Xiao-Yuan PAN
;
Jun-Li CAO
;
Hong-Xing ZHANG
Author Information
- Keywords: ketamine; depression; antidepressant; monoamin-ergic system; glutamatergic system; dopaminergic systems
- From: Chinese Pharmacological Bulletin 2024;40(9):1622-1627
- CountryChina
- Language:Chinese
- Abstract: Major depressive disorder(MDD)is a prevalent con-dition associated with substantial impairment and low remission rates.Traditional antidepressants demonstrate delayed effects,low cure rate,and inadequate therapeutic effectiveness for man-aging treatment-resistant depression(TRD).Several studies have shown that ketamine,a non-selective N-methyl-D-aspartate receptor(NMDAR)antagonist,can produce rapid and sustained antidepressant effects.Ketamine has demonstrated efficacy for reducing suicidality in TRD patients.However,the pharmaco-logical mechanism for ketamine's antidepressant effects remains incompletely understood.Previous research suggests that the an-tidepressant effects of ketamine may involve the monoaminergic,glutamatergic and dopaminergic systems.This paper provides an overview of the pharmacological mechanism for ketamine's anti-depressant effects and discuss the potential directions for future research.
