Reflection and prospect on mechanism of dopamine reward system involvement in depression loop and traditional Chinese medicine intervention research
- VernacularTitle:多巴胺奖赏系统参与抑郁环路机制及中医药干预研究思考与展望
- Author:
Zhuo-Xian LI
1
;
Liu-Chang ZHOU
;
Li-Hong YE
;
Di DENG
;
Jin-Lan ZHAO
;
Ya-Fei SHI
;
Rong ZHANG
Author Information
- Keywords: depression; reward system; neural circuit; dopa-mine; ventral dorsal tegmental area; nucleus accumbens
- From: Chinese Pharmacological Bulletin 2024;40(8):1424-1429
- CountryChina
- Language:Chinese
- Abstract: In the process of seeking new strategies to improve the efficacy of antidepressants,traditional Chinese medicine inter-vention has gradually revealed its unique prevention and treat-ment advantages.The dopamine reward system is closely in-volved in the pathological occurrence and development of depres-sion.Currently,research has mostly focused on the functional mechanism of a specific nucleus in the dopamine reward system,and there is less research focused on the functional mechanism of the neural circuit.In the current micro research on reward cir-cuits,the association between abnormal reward circuits and neg-ative emotions such as anxiety and depression has been widely recognized.Traditional Chinese medicine intervention can exert antidepressant effects by influencing reward circuits.This article provides a review on the loop mechanism of dopamine reward system involvement in depression and research on traditional Chinese medicine intervention.
