Advances in metabolic reprogramming in heart failure
- VernacularTitle:代谢重编程在心力衰竭中的研究进展
- Author:
Lei HUANG
1
;
Wen-Wen LI
;
Pei-Wen WENG
;
Shan GAO
Author Information
- Keywords: heart failure; metabolic reprogramming; lipid me-tabolism; glucose; ketone bodies; mitochondria
- From: Chinese Pharmacological Bulletin 2024;40(8):1418-1423
- CountryChina
- Language:Chinese
- Abstract: Adenosine triphosphate(ATP)production in cardio-myocytes in healthy heart depends primarily on the oxidative phosphorylation of fatty acids and,to a lesser extent,on the oxi-dation or glycolysis of glucose.Patients with heart failure devel-op severe disturbances in energy metabolism,including disturb-ances in substrate uptake and utilization,oxidative phosphoryla-tion,and ATP shuttling,resulting in inadequate cardiac energy supply.By intervening in energy metabolism pathways,cardiac efficiency can be increased,energy production deficits can be reduced,and cardiac function can be improved in patients with heart failure.We hence have reviewed and outlined the mecha-nisms and therapeutic implications of metabolic changes during heart failure.
