Development of nanographene oxide as clinical drug carrier in cancer therapy

VernacularTitle:纳米氧化石墨烯作为临床药物载体在肿瘤治疗中的研究
Author: Chun-Lian ZHONG ^{1
,

2} ; Chang-Jian FANG ; Gui-Yu ZHOU ; Hui-Ling ZHU ; Tang ZHENG ; Wan-Jing ZHUANG ; Jian LIU ; Yu-Sheng LU
Author Information

1. 闽江学院材料与化学工程学院,福建省智能药物闽台港澳科技合作基地
2. 闽江学院福州海洋研究院,海洋药物研发中心,福建福州 350108
Keywords: cancer therapy; nanographene oxide; drug load-ing; targeted delivery; photothermal therapy; combination thera-py
From: Chinese Pharmacological Bulletin 2024;40(8):1413-1418
CountryChina
Language:Chinese
Abstract: Immunotherapy is an important breakthrough in canc-er treatment.Unfortunately,low drug concentration in tumor sites almost ineffectively initiates immune responses and thereby severely limits immune therapy applications in clinics.Nanoma-terials are well-recognized drug delivery system in cancer thera-py.Nanographene oxide(NGO)have shown immense perti-nence for anti-cancer drug delivery owing to their ultra-high sur-face area,chemical stability,good biocompatibility and excel-lent photosensitivity.In addition,functionalized modifications on the surface of NGO increase tumor targeting and minimize cy-totoxicity.This study focuses on reviewing the literature and up-dates on NGO in drug delivery and discussing the possibilities and challenges of NGO in cancer synergetic therapy.