Review of microglial efferocytosis in ischemic stroke
- VernacularTitle:缺血性脑卒中后小胶质细胞胞葬作用的研究进展
- Author:
Ping-Long FAN
1
,
2
;
Hua-Qing LAI
;
Zhao ZHANG
;
Shi-Feng CHU
;
Nai-Hong CHEN
Author Information
- Keywords: microglia; efferocytosis; ischemic stroke; apopto-sis; neuroinflammation; pharmacotherapy
- From: Chinese Pharmacological Bulletin 2024;40(8):1407-1412
- CountryChina
- Language:Chinese
- Abstract: Once ischemic stroke occurs,severely insufficient blood supply causes massive neuronal apoptosis and necrosis,leading to the release of damage-associated molecular patterns(DAMPs)that exacerbate neuroinflammation and worsen brain damage.As the resident efferocytes in central nervous system,microglia possess the capability to phagocytose and eliminate ap-optotic cells by efferocytosis before necrosis occurs,thereby mit-igating the release of DAMPs and the accumulation of cellular debris.This process is crucial for neuroinflammation reduction and neurorestoration.Hence,a comprehensive understanding of the regulatory mechanism of microglial efferocytosis post-ische-mia,as well as its impact on neuroinflammation and cerebral damage,has the potential to advance diagnostic and therapeutic approaches for ischemic stroke.Here,we outline the molecular mechanisms and signaling pathways involved in microglial effero-cytosis following ischemic stroke,and summarize the research progress on drugs targeting microglial efferocytosis to enhance stroke prognosis.
