Research progress of non-coding RNAs in regulating endothelial to mesenchymal transition in diseases
10.12360/CPB202210064
- VernacularTitle:非编码RNA调控内皮间质转化在疾病中的研究进展
- Author:
Wei QIN
1
;
Zhi-Jie LUO
;
Rui-Xue RONG
;
Xue-Ying CHEN
Author Information
1. 济宁医学院药学院,山东日照 276800
- Keywords:
non-coding RNAs;
endothelial to mesenchymal transition;
therapeutic target;
cardiovascular disease;
organ fi-brosis;
tumor
- From:
Chinese Pharmacological Bulletin
2024;40(7):1215-1221
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial to mesenchymal transition(EndMT)is a process in which endothelial cells lose their endothelial pheno-type and function and gain mesenchymal phenotype and func-tion.During the embryonic period,EndMT is an essential mech-anism for the development of heart valves,pulmonary arteries and aorta.In recent years,numerous studies have shown that EndMT is also involved in the occurrence and development of cardiovascular diseases such as atherosclerosis,cardiac fibrosis,pulmonary hypertension,and cerebrovascular malformation.In addition,EndMT is also an important mechanism of other organ fibrosis and tumors.Non-coding RNAs(ncRNAs)refer to RNAs that are transcribed from the genome but do not translate into proteins.Studies have shown that the abnormal expression of ncRNAs can participate in various diseases by regulating End-MT.Such ncRNAs with regulatory functions mainly include mi-croRNA(miRNA),long non-coding RNA(lncRNA)and cir-cular RNA(circRNA).This review summarizes the molecular mechanisms by which ncRNAs regulate EndMT in various disea-ses,looking forward to the application prospects of ncRNAs in the treatment of EndMT-related diseases.
