Interaction between neuron-glial cell gap junction and neural circuit

VernacularTitle:神经元-胶质细胞缝隙连接与神经环路的相互作用
Author: Hong-Bin WANG ^{1
,

2} ; Jiao YAO ; Hui-Qin WANG ; Zhi-Feng TIAN ; Qi-Di AI ; Mei-Yu LIN ; Yan-Tao YANG ; Song-Wei YANG ; Nai-Hong CHEN
Author Information

1. 湖南中医药大学药学院
2. 湖南省中药饮片标准化及功能工程技术研究中心,湖南长沙 410208
Keywords: neurons; glial cells; gap junction; electrical syn-apses; neural circuits; connexin 36; connexin 43
From: Chinese Pharmacological Bulletin 2024;40(7):1210-1214
CountryChina
Language:Chinese
Abstract: Gap junction(GJ),also known as gap junction,is widely found between neurons and glial cells,and can connect neighboring cells and mediate the transmission of electrical sig-nals between neighboring cells.The GJ channel,which exists between neurons and mediates intercellular electrical signaling,is also known as an electrical synapse.Connexins(Cxs)are the molecular basis of GJ,and are expressed to different degrees in different neurons and glial cells.The presence of GJ mediates different functions among neurons and glial cells,which further influences the establishment of various mature neural circuits,re-flecting the importance of GJ in the maintenance of neural cir-cuits.This review summarizes the relationship between GJ and neural circuits in relation to the effects of GJ and different Cxs on neurons and glial cells,providing new research ideas for the treatment of neuropsychiatric disorders.