Research progress of mitochondrial quality control in methamphetamine-induced neurotoxicity
- VernacularTitle:线粒体质量调控在甲基苯丙胺诱导神经毒性损害中的作用研究进展
- Author:
Qian-Yun NIE
1
,
2
;
Wen-Juan DONG
;
Gen-Meng YANG
;
Li-Xiang QIN
;
Chun-Hui SONG
;
Li-Hua LI
;
Shi-Jun HONG
Author Information
- Keywords: methamphetamine; mitochondrial quality control; mitochondrial biogenesis; mitochondrial dynamics; mitophagy; neurotoxicity
- From: Chinese Pharmacological Bulletin 2024;40(7):1201-1205
- CountryChina
- Language:Chinese
- Abstract: Methamphetamine abuse is a major public health problem in the world,and in recent years,methamphetamine is also the most abused synthetic drug in China.The neurotoxic or addiction mechanism of methamphetamine has not been fully clarified,and there is still a lack of specific withdrawal methods and drugs for methamphetamine abuse.Mitochondria are not on-ly the organelles to which methamphetamine directly produces toxic effects,but also participate in regulating the neurotoxic damage process of methamphetamine.Mitochondrial quality is the regulatory basis for maintaining mitochondrial homeostasis and is regulated by three main mechanisms,which are mitochon-drial biogenesis,mitochondrial dynamic,and mitophagy.This review summarizes the research progress of mitochondrial quality control in methamphetamine-induced neurotoxicity,which may provide theoretical support for further research on the mechanism of methamphetamine neurotoxicity and development the mito-chondria-targeting drugs.
