Research progress of inducing ferroptosis of cancer stem cells against colorectal cancer
- VernacularTitle:诱导癌干细胞铁死亡抗结直肠癌的研究进展
- Author:
Li-Na GONG
1
;
Meng-Ling YUAN
;
Xue-Ying CHENG
;
Chen-Yang XU
;
Jun PAN
;
Qiu-Tong CHEN
;
Ling WANG
;
Zi-Li ZHANG
;
Mei GUO
Author Information
- Keywords: cancer stem cell; ferroptosis; colorectal cancer; reactive oxygen species; lipid peroxidation; iron ion
- From: Chinese Pharmacological Bulletin 2024;40(6):1030-1034
- CountryChina
- Language:Chinese
- Abstract: Cancer stem cell(CSC)are the"seed"cells in the occurrence,development,metastasis and recurrence of colorectal cancer.Targeted killing of CSC provides a new target for anti-colorectal cancer therapy.Ferroptosis is an iron-dependent cell death mode due to the abnormal accumulation of intracellular i-ron ions,which results in the massive reactive oxygen species(ROS)and lipid peroxides,leading to cell death.Studies have shown that cancer stem cells are more enriched in iron ions than non-CSC,which provides a new perspective for targeting ferropto-sis in cancer stem cells against colorectal cancer.This article re-views the research progress of inducing CSC ferroptosis in the treatment of colorectal cancer,such as targeted regulation of SLC7A11 expression in CSC,chelating iron in CSC lysosomes,targeting CSC phenotypic plasticity,reversing CSC iron homeo-stasis,and targeting CSC lipid droplet metabolism induce CSC ferroptosis,which provides new ideas for anti-tumor therapy.
