Regulation mechanism of PI4KⅢβ in physiological and pathological states
- VernacularTitle:生理病理状态下PI4KⅢβ的调控机制
- Author:
Tian-Tian ZHU
1
,
2
;
Yu ZHANG
;
Yu-Qi SANG
;
Li LI
;
Shuang-Zhu YOU
;
Jin-Long QI
;
Dong-Yang HUANG
;
Hai-Lin ZHANG
Author Information
- Keywords: PI4KⅢβ; phosphatidylinositol 4-phosphate; mem-brane recruitment; viral infection; bacterial infection; malaria; neurological diseases
- From: Chinese Pharmacological Bulletin 2024;40(6):1025-1030
- CountryChina
- Language:Chinese
- Abstract: Phosphatidylinositol 4 kinases are the initial and key molecules of the phosphatidyl inositol signaling pathway.Among them,the phosphatidylinositol 4-kinaseⅢ β(PI4KⅢβ)is in-volved in the synthesis of the Golgi PI4P pool,playing a vital role in numerous physiological processes.Meanwhile,the en-zyme is an important host factor mediating the replication of some pathogenic RNA viruses,and participating in other patho-logical processes such as bacterial infection and malaria.In ad-dition,studies have shown that the function of PI4KⅢβ is regu-lated by numerous factors,including host and viral protein bind-ing partners.This review will discuss the structure and the phys-iopathology regulatory mechanism of PI4KⅢβ.
