Efficacy and safety of remimazolam tosylate for general anesthesia in morbidly obese patients
- VernacularTitle:瑞马唑仑用于病态肥胖患者全身麻醉的有效性和安全性
- Author:
Gong CHEN
1
;
Yan-Xi LU
;
Jin LI
;
Fan ZHANG
;
Can-Can CHENG
;
Xin-Lin YIN
;
Sai-Ying WANG
;
Huan CHANG
Author Information
- Keywords: propofol; remimazolam; morbid obesity; post-induction hypotension; laparoscopic sleeve gas-trectomy; hemodynamics
- From: Chinese Pharmacological Bulletin 2024;40(5):859-864
- CountryChina
- Language:Chinese
- Abstract: Aim To evaluate the effectiveness and safety of remimazolam tosylate for administering general anesthesia in morbidly obese patients.Methods This clinical trial was conducted at a single center from De-cember 2021 to October 2023.It assessed 108 morbid-ly obese patients(body mass index,BMI≥40)who underwent laparoscopic sleeve gastrectomy.Patients were randomly assigned to either the remimazaolam group(Group R)or the propofol group(Group P)for general anesthesia induction and maintenance.The primary outcome was to compare the incidence of ad-verse events and postoperative recovery characteristics between the two groups.Results During induction pe-riod,the incidence of adverse events was higher in group P,including hypotension(P＜0.01),hypox-emia(P＜0.05),bradycardia(P＜0.01),and in-creased vasopressor requirement(P＜0.05).The time to loss of consciousness and BIS falling to 60 was shor-ter in group P than in group R(P＜0.01).There were no statistically significant differences between the two groups in terms of postoperative quality of recovery(QoR-40 score),24-hour postoperative pain visual an-alogue scale(VAS)scores and morphine consump-tion.In conclusion,remimazolam tosylate,utilized for anesthesia induction in morbidly obese patients,signif-icantly reduced hypotension and hypoxemia compared to propofol,while it could also maintain similar postop-erative recovery quality.Conclusions Remimazolam is effective in reducing the incidence of hypotension and hypoxaemia during the induction period of general anaesthesia in morbidly obese patients and it is compa-rable to propofol in terms of quality of postoperative re-covery.
