Advances in pharmacological effects of ginseng,acorus calamus and its couplet medicine on Alzheimer's disease
- VernacularTitle:人参、石菖蒲及其药对防治阿尔茨海默症的药理作用研究进展
- Author:
Yu-Chen ZHU
1
,
2
;
Bo-Yu KUANG
;
Jin-Ping LIANG
;
Xiao-Lei PEI
;
Jia-Zhu ZHAO
;
Shi-Feng CHU
;
Nai-Hong CHEN
;
Yan-Tao YANG
Author Information
- Keywords: ginseng; acorus calamus; couplet medicine; Alzhe-imer's disease; mechanism of action; learning and memorizing
- From: Chinese Pharmacological Bulletin 2024;40(5):817-822
- CountryChina
- Language:Chinese
- Abstract: The pathogenesis of Alzheimer's disease(AD)is complex and unclear.Existing drugs can only alleviate its symp-toms,and there is an urgent need to develop effective therapeutic drugs.As the representative drugs of tonic and enlightening medicine,ginseng and acorus calamus have pharmacological effects to improve memory,improve learning ability and reduce cognitive impairment,which are commonly used in Chinese med-icine for the treatment of dementia.The combination of ginseng and acorus calamus can further promote the active ingredients in-to brain to exert their medicinal effects,and delay the process of AD through anti-inflammatory,anti-oxidative stress,modulation of neuronal-synaptic plasticity and other multiple pathways,with multi-level,multi-system and multi-target action characteristics.This paper attempts to summarize the existing research results and lay the foundation for further exploring the synergistic mech-anism of action of ginseng-acorus calamus combination and the dose-effect relationship of the combination,so as to provide a sci-entific basis for the development of innovative Chinese medicines for the prevention and treatment of AD.
