Research progress on the effect of diacerein in the regulation of glucose and lipid metabolism
- VernacularTitle:双醋瑞因调节糖脂代谢作用的研究进展
- Author:
Ying-Ying XIANG
1
,
2
;
Ruo-Nan ZHOU
;
Wen-Bin SHANG
Author Information
- Keywords: diacerein; rhein; glucose metabolism; lipid metab-olism; insulin resistance; pancreatic islet β-cells
- From: Chinese Pharmacological Bulletin 2024;40(5):811-816
- CountryChina
- Language:Chinese
- Abstract: Diacerein(DCN),an interleukin-1β(IL-1β)inhib-itor,has been clinically used for osteoarthritis.Chronic inflam-mation is considered as a causal factor of metabolic disorders,such as obesity and type 2 diabetes.Anti-inflammation therapy has emerged as an important strategy for improving the dysregu-lation of glucose and lipid metabolism.A series of domestic and international studies have shown that DCN regulates the disorders of glucose and lipid,which implies its potential application for the treatment of metabolic diseases.This paper summarized the effects and mechanisms of DCN on regulating glucose homeosta-sis and lipid metabolism.The mechanisms might involve the im-munomodulatory and anti-inflammatory action,the effect of anti-oxidative stress,the modulation of adipokine secretion,the regu-lation of programmed cell death,and the enhancement of insulin signaling transduction.These findings provide perspective for further development and application of DCN.
