Research progress of cathepsins in neurodegenerative diseases
10.12007/j.issn.0258-4646.2024.11.014
- VernacularTitle:组织蛋白酶在神经系统变性疾病中的研究进展
- Author:
Sitong YAO
1
;
Weiqi XU
;
Shuyan CONG
Author Information
1. 中国医科大学附属盛京医院神经内科,沈阳 110004
- Keywords:
cathepsin;
neurodegenerative disease;
research progress
- From:
Journal of China Medical University
2024;53(11):1036-1042,1050
- CountryChina
- Language:Chinese
-
Abstract:
Cathepsins,the most abundant hydrolases in lysosomes,are responsible for the degradation of various substrates.Increasing evidence suggests that cathepsins play important roles in neurodegenerative diseases.Cathepsins affect the progression of diseases by regu-lating the aggregation of abnormal proteins(e.g.α-synuclein,amyloid β-protein,huntington).Abnormal expression levels and activity and gene mutations of cathepsin B,D,and L in the nervous system can lead to the occurrence and development of neurodegenerative diseases.This review summarizes the research progress on cathepsins in neurodegenerative diseases in recent years,with a view to providing a basis for the early diagnosis and treatment of these diseases.
