Efficacy of transcatheter aortic valve replacement in patients with severe aortic stenosis
10.12007/j.issn.0258-4646.2024.11.006
- VernacularTitle:经导管主动脉瓣置换术治疗主动脉瓣重度狭窄的疗效评价
- Author:
Liu LI
1
;
Qinghou ZHENG
;
Le WANG
;
Mingqi ZHENG
;
Gang LIU
;
Shuo WANG
Author Information
1. 河北医科大学第一医院心内科,石家庄 050011
- Keywords:
transcatheter aortic valve replacement;
severe aortic stenosis;
cognitive function
- From:
Journal of China Medical University
2024;53(11):989-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of transcatheter aortic valve replacement(TAVR)in patients with severe aortic valve stenosis.Methods This study included 46 patients with severe aortic valve stenosis who underwent TAVR and completed a six-month follow-up at the Heart Center of the First Hospital of Hebei Medical University between May 2020 and May 2023.All patients underwent a preoperative examination,mini-mental state examination(MMSE),the Montreal cognitive assessment scale(MOCA),and the following safety indicators of surgery,including immediate success rate of valve implantation,valve displacement,death,heart conduction block,perivalve leakage,coronary occlusion,stroke,approach vessel rupture,cardiac tamponade,aortic dissection,and massive bleeding.Effec-tiveness indicators included clinical symptoms,BNP,sST2,and cardiac color Doppler ultrasound preoperatively and one day,seven days,three months,and six months postoperatively.Cognitive function indicators(MMSE and MOCA),were used preoperatively and three and six months postoperatively.The efficacy of transcatheter aortic was evaluated using these indicators.Results The immediate success rate of valve implantation was 100％,with one case of valve displacement,four cases of new bundle branch block,two cases of perivalve leakage,two cases of stroke,one case of inlet vessel rupture,one case of major bleeding,and no deaths,coronary artery occlusion,car-diac tamponade,or aortic dissection.Clinical symptoms improved significantly postoperatively,with 30 cases of NYHA grades Ⅰ to Ⅱbeing significantly higher than the 18 cases preoperatively.The indicators of cardiac function,BNP,and sST2 significantly decreased,and the maximum aortic valve cross-valve flow velocity,aortic valve systolic cross-valve pressure difference,average aortic valve cross-valve pressure difference,and left ventricular end-diastolic diameter significantly improved.The MMSE and MOCA showed significant improve-ments three and six months postoperatively.Conclusion TAVR is a safe and effective method to improve cognitive function in patients with severe aortic stenosis.
