Correlation between overactive bladder and allergies in children
10.12007/j.issn.0258-4646.2024.10.012
- VernacularTitle:儿童膀胱过度活动综合征与过敏的相关性分析
- Author:
Ningning WANG
1
;
Aimin SUN
;
Yue DU
Author Information
1. 中国医科大学附属盛京医院小儿肾脏风湿科,沈阳 110004
- Keywords:
overactive bladder;
atopic constitution;
bradykinin;
substance P
- From:
Journal of China Medical University
2024;53(10):939-943,948
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the clinical correlation between overactive bladder(OAB)and allergies in children.Methods The clinical characteristics of 663 children diagnosed with OAB in outpatient clinics between January 2020 and January 2022 were retro-spectively analyzed,and logistic regression was used to analyze the risk factors for OAB and evaluate the effect of antihistamine drugs on OAB.Blood and urine samples of some children with OAB were collected to analyze the expression levels of bradykinin and substance P.Results A history of eczema,urticaria,pruritus,mosquito bites,allergic rhinitis,allergic cough with asthma,food allergies,constipation,and total blood IgE levels were risk factors for OAB in children(P＜0.05).The efficacy rate of antihistamine treatment in children with OAB was 95.5％,and no adverse reactions were observed,indicating that the efficacy and safety of OAB in children receiving antihista-mine treatment were good,and the proportion of children with OAB and urticaria in the antihistamine treatment group was higher(P＜0.05).The total blood IgE levels in children with OAB in the effective group of antihistamine treatment were higher than those in the ineffective group(P＜0.05).In addition,the expression level of bradykinin in the urine of children with OAB was significantly higher than in healthy children(P＜0.05),while the level of substance P was not significantly increased(P＞0.05).Conclusion OAB in chil-dren are related to their allergic status,children's previous respiratory,digestive tract,and skin allergies,and significantly elevated blood IgE levels are risk factors for OAB in children.Antihistamine treatment of OAB in children is safe and effective.OAB in children may be related to urine bradykinin.
