Pathological features of lacrimal gland mucosa-associated lymphoid tissue lymphoma and the expression and significance of BCL10 and MALT1
10.12007/j.issn.0258-4646.2024.09.007
- VernacularTitle:泪腺黏膜相关淋巴组织淋巴瘤的病理特征及BCL10和MALT1的表达和意义
- Author:
Shuai JIANG
1
;
Zhijun DONG
;
Weili DONG
;
Junru LIU
;
Ziping ZHANG
;
Yan HEI
;
Xinji YANG
Author Information
1. 承德医学院附属医院眼科,河北 承德 067000
- Keywords:
lacrimal gland mucosa-associated lymphoid tissue lymphoma;
pathological morphology;
hematoxylin-eosin staining;
immu-nohistochemical staining;
BCL10;
MALT1
- From:
Journal of China Medical University
2024;53(9):804-808
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathomorphological features of mucosa-associated lymphoid tissue(MALT)lymphoma of the lacrimal gland and the expression and significance of BCL10 and MALT1 in tumor tissues.Methods Diseased lacrimal gland tissue specimens from 19 patients with lacrimal gland MALT lymphoma(19 eyes,including nine right eyes and ten left eyes)were selected as the experimental group,and normal lacrimal gland tissue specimens from eight patients with orbital content removal(eight eyes,including three right eyes and five left eyes)were selected as the control group.Hematoxylin-eosin(HE)staining was performed to observe the mor-phological characteristics of the lacrimal gland tissues,and immunohistochemical(IHC)staining was performed to observe the expression of BCL10 and MALT1 in the lacrimal gland tissues.Results In the experimental group,marginal B cells,monocyte-like tumor cells,small lymphocyte-like tumor cells,and plasma cell-like tumor cells appeared in the marginal zone.Large cells were occasionally distri-buted among these cells.The tumor cells invaded the lymphoid follicles and epithelium,destroyed normal tissue structure,and formed follicular colonization and lymphoepithelial lesions.The positive expression area of BCL10 and MALT1 in the experimental group was sig-nificantly larger than that in the control group(Z=-2.177,P=0.029;t=3.237,P=0.003).Conclusion Lacrimal gland MALT lymphoma shows pathological changes in diffusely distributed marginal B cells and tumor cells with diverse morphology,acquired lymphoid follicles,and scattered distribution of large cells.This may be related to apoptosis blockage caused by the upregulation of BCL10 and MALT1 expression.
