Expression of IL-18,IL-18BP,and IL-18R in peripheral blood B lymphocytes and monocytes of patients with atopic dermatitis
10.12007/j.issn.0258-4646.2024.09.003
- VernacularTitle:IL-18、IL-18BP、IL-18R在特应性皮炎患者外周血B淋巴细胞及单核细胞中的表达
- Author:
Huitong LI
1
;
Luning REN
;
Fei WANG
;
Dongmei YANG
;
Hongyang DU
Author Information
1. 锦州医科大学附属第一医院皮肤科,辽宁 锦州 121000
- Keywords:
atopic dermatitis;
B lymphocytes;
monocyte;
interlukin-18;
interlukin-18BP;
interlukin-18R
- From:
Journal of China Medical University
2024;53(9):782-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of IL-18,IL-18BP,and IL-18R in the peripheral blood B lymphocytes and mono-cytes of patients with atopic dermatitis(AD).Methods Peripheral venous blood was collected from 28 patients with AD and 21 healthy controls,and stimulated with Artemisia sieversiana wild allergen extract,house dust mite allergen extract,or Platanus pollen allergen extract.The expression of IL-18+,IL-18BP+,and IL-18R+in B lymphocytes and monocytes was measured using flow cytometry.Results Compared with the healthy control group,the proportions of IL-18+,IL-18BP+,and IL-18R+cells in the B lymphocyte group of patients with AD at rest increased 2.01-,10.35-,and 20.85-fold,respectively.The proportions of IL-18+and IL-18BP+cells in monocytes increased 5.51-and 41.88-fold,respectively,whereas the proportion of IL-18R+cells did not differ significantly between the groups.Conclusion IL-18,IL-18BP,and IL-18R in B lymphocytes and monocytes may play an important role in AD.IL-18,IL-18BP,and IL-18R may be potential targets for the treatment of AD.
